The concomitant use of opioids with other medications that affect the serotonergic neurotransmitter technique has resulted in serotonin syndrome.
It is vital that Promethazine HCl Oral Alternative is measured with the precise measuring machine (see PRECAUTIONS-Data for People). A family teaspoon is not really an accurate measuring unit and may lead to overdosage, particularly when 50 % a teaspoon is usually to be measured.
Anaphylactic reactions, as adjunctive therapy to epinephrine and also other standard measures, after the acute manifestations have been managed.
Pregnancy Exams: Diagnostic pregnancy checks based upon immunological reactions between HCG and anti-HCG might cause Bogus-negative or Fake-positive interpretations.
Stay away from the use of Promethazine HCl and Codeine Phosphate Oral Remedy in adolescents 12 to eighteen years of age who produce other hazard things that may increase their sensitivity to the respiratory depressant effects of codeine.
Focus–Adverse Response Interactions There's a relationship involving growing codeine plasma focus and raising frequency of dose- associated opioid adverse reactions which include nausea, vomiting, CNS outcomes, and respiratory despair.
Promethazine HCl and Codeine Phosphate Oral Alternative need to be applied with caution in individuals with bone- marrow despair. Leukopenia and agranulocytosis are described, commonly when promethazine has actually been Employed in Affiliation with other recognised marrow-toxic agents.
Amplified risk of seizures. Promethazine HCl Oral Solution should be utilized with warning in patients with seizures or who are on other medicines which may also improve the chance of seizures.
Treatment of Overdose Remedy of overdosage is pushed by the general medical presentation, and includes discontinuation of Promethazine HCl and Codeine Phosphate Oral Resolution along with establishment of suitable therapy. Give Major interest for the reestablishment of satisfactory respiratory exchange by provision of a patent and guarded airway and also the establishment of assisted or managed ventilation.
An increased chance of distinct malformations with codeine publicity which include respiratory malformations, spina bifida and congenital coronary heart defects had been described in a few experiments.
Significant drowsiness and diminished mental alertness. Promethazine HCl Oral Answer may cause drowsiness which can impair your capacity to trip a motorbike, push an automobile, or operate equipment.
This may be worsened if taken with Alcoholic beverages or other medicine that also lead to central nervous program (CNS) slowing for instance sedatives, agony medicines, tranquilizers or specified medication for melancholy.
Codeine and promethazine, two in the Lively substances in Promethazine HCl and Codeine Phosphate Oral Answer, might create marked drowsiness and impair the psychological and/or physical capabilities necessary to the overall performance of probably harmful jobs for example driving click here an auto or functioning machinery. Suggest patients to prevent partaking in harmful duties demanding mental alertness and motor coordination immediately after ingestion of Promethazine HCl and Codeine Phosphate Oral Remedy.
The therapy of option for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. In case vasopressors are considered for that management of significant hypotension which doesn't reply to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be regarded.